Clinical Evaluation of the Effect of Anti-allergic Mattress Covers in Patients with Moderate to Seve

Abstract

Background: The use of anti-allergic mattress covers in patients with asthma can result in a large reduction in the level of house dust mite allergen in dust samples. Apart from a reduction in histamine induced bronchial hyperresponsiveness, there are few data on the effect of mattress covers on clinical efficacy and quality of life in patients with moderate to severe asthma.

Methods: Thirty patients with asthma and house dust mite allergy were studied in a randomised, double blind, placebo controlled study. Before and after using anti-allergic covers for 1 year, dust was collected from the mattresses to determine concentrations of Dermatophagoides pteronyssinus (Der p 1), and bronchial hyperresponsiveness and quality of life were measured. The patients scored their symptoms (lungs and nose), morning and evening peak flow values, and rescue medication for 14 days before and after the intervention period.

Results: There was a significant reduction in the concentration of Der p 1 in the dust collected from the mattresses in the actively treated group after 1 year compared with before treatment; no change was found in the placebo group. In both the actively treated and placebo groups there was no significant improvement in PC20 histamine. Quality of life improved similarly in both groups. The symptom score of the lower airways did not significantly change in either group. A significant decrease in nasal symptom score was seen in the actively treated group compared with before treatment, but there was no significant difference between the groups. No changes in morning and evening peak flow values, peak flow variability, nor in the use of rescue medication were found in either group.

Conclusion: The use of anti-allergic mattress covers results in significant reductions in Der p 1 concentrations in carpet-free bedrooms. However, in patients with moderate to severe asthma, airways hyperresponsiveness and clinical parameters are not affected by this effective allergen avoidance.

METHODS

Patients

Thirty eight patients aged 11-44 years with a history of asthma and house dust mite allergy were recruited from the outpatients department of Asthmacenter Heideheuvel in Hilversum, The Netherlands, from January 1996 to December 1998. Informed consent was obtained from the patients or their parents. The patients were selected on the basis of increased bronchial responsiveness to histamine inhalation (PC20 1 μg Der p 1/g dust). All patients had FEV1 values >60% (predicted value). Patients had no history of respiratory tract infections in the previous 6 weeks or severe asthma attacks in the previous 6 months. None had received oral corticosteroids in the previous 6 months.

All patients gave informed consent. The medical ethics committee of Asthmacenter Heideheuvel approved the study.

Study design

The study was of a randomised, placebo controlled, double blind, parallel group design, comparing the effect of allergen impermeable encasings on the mattresses, pillows and bedcovers during 1 year with matching placebo encasings.

At the start of the study a trained respiratory nurse visited the patients to collect dust samples from the mattresses of the patients for Der p 1 measurement and to note the allergen avoidance measures already present in the house. All patients included in the study had smooth bedroom floors. Patients were instructed to wash their sheets each week at 60°C. Apart from the mattress encasings, no other allergen avoidance measures were taken. At the end of the study the same nurse visited the houses again to collect dust from the mattress covers.

The patients were included during the entire year; the inclusion period was 2 years. Pollen allergic patients were tested outside the pollen season.

At the first visit patients underwent clinical evaluation. FEV1 and vital capacity (VC) values were measured, skin tests performed, and a PC20 histamine was assessed. Medication was withheld before the study period: inhaled steroids and sodium cromoglycate for 1 week before the bronchial histamine provocation test; theophyllines, oral β2 adrenergic agents, long acting inhaled β2 adrenergic agents, and antihistamines for 48 hours, and inhaled short acting β2 adrenergic drugs for 6 hours before the tests.

Collection and extraction of house dust

Before the intervention, at 4 and 8 months, and at the end of the intervention mattress dust was collected by the same vacuum cleaner (Philips Vitall 377, 1300 watt, Philips, Eindhoven, The Netherlands) from the whole mattress during 2 minutes with a special filter device (ALK, Horsholm, Denmark). At the start of the study dust was collected directly from the mattresses; at the end of the study dust was collected on top of the encasings. The filters were stored in the freezer at -20°C until analysis at the end of the study.

Der p 1 antigen was measured using enzyme linked immunosorbent assay (ELISA). Monoclonal antibodies against Der p 1 were immobilised on a 96-well plate. Incubation with the dust extracts was followed by a second incubation step with a polyclonal antibody (horseradish peroxidase, HRP). After adding 1,2-phenyldiamine HCl (OPD) as substrate, absorption at 490 nm was measured using an ELISA reader.

Histamine challenge

Histamine phosphate solutions (doubling concentrations from 0.25 to 32 mg/ml) were administered through a De Vilbiss 646 nebuliser with a gauged output of 0.13 mg/ml. The nebuliser was mounted on a valve box with an aerosol filter. The nebulisation time was 30 seconds, during which the patient was instructed to breath quietly. The test was started with inhalation of a phosphate buffer aerosol. Before inhalation three measurements of VC and FEV1 were performed (Jaeger Masterscreen). FEV1 was measured after each concentration. PC20 histamine was derived by linear interpolation.

Mattress encasings

Mattresses, pillows, and bedding in the intervention group were encased with covers supplied by Cara C'air (Allergy Control AC btm Velserbroek, Netherlands). The matched placebo covers were made by the same company. The encasings were placed in position by a research nurse and left in situ for 1 year.

Quality of life

Quality of life was assessed by the Quality of Life for Respiratory Illness Questionnaire (QoL-RIQ).17 The QoL-RIQ is a disease specific quality of life questionnaire for patients with asthma and COPD which consists of 55 items divided into seven domains: breathing problems (9 items), physical problems (9 items), emotions (9 items), situations triggering/enhancing breathing problems (7 items), general activities (4 items), daily and domestic activities (10 items), social activities, relationships and sexuality (7 items). To focus the questions on the patients' experiences, items are formulated in terms of "how much trouble" they had experienced from the mentioned symptom or emotion. In the case of activity related items, questions are stated in terms of "how much they were impeded" by their disorder in carrying out that specific activity. Patients are asked to give their answer on a 70 point Likert scale ranging from "not at all" to "extremely" troubled or impeded. Reliability (test-retest, internal consistency) and validity have been proven.17

Clinical parameters

During the 14 day period before the intervention and at the end of the 12 month intervention period the patients were asked to keep diary cards in which asthma and nasal symptoms, peak flow values, and medication use were recorded twice daily. Asthma symptoms included dyspnoea, cough, expectoration, and wheezing. Nasal symptoms included nasal blockage, rhinorrhoea, sneezing, and itching. Each item was scored on a scale from 0 (no symptoms) to 4 (severe symptoms).

The patients were trained in performing peak flow manoeuvres with the mini-Wright meter. They were instructed to perform three readings and to record the highest value in the morning when waking and in the evening before sleeping.

Patients were asked to continue their normal inhalation medication and to record extra rescue medication in case they needed it.

Data analysis

Statistical analyses were performed with SPSS. Comparisons within groups (before and after intervention) were made with the Wilcoxon signed rank test. Logarithmic data were analysed using the sign test. The Mann-Whitney U test was used for between group comparisons. p values of 0.5)18 were seen in breathing problems, physical problems related to chest problems, triggering/enhancing circumstances, and total score in both the treated and the placebo groups. Although the size of the improvements did not significantly differ between the two groups, improvements within the treated group were significant.

Clinical parameters

Baseline values of asthma symptom scores showed no significant differences between the groups (table 2). The median pulmonary symptom score did not change significantly over 1 year in either group. There was a significant decrease in the nasal symptom score in the treated group (p=0.04) but not in the placebo group; the difference between the two groups was not significant. Baseline PEF values (morning and evening) were comparable for both groups (table 3). No significant changes in morning and evening PEF, peak flow variability, or the use of rescue medication occurred in either group following the 1 year intervention.View this table:View inline

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Table 2

Symptom score before and after intervention (median values of 14 days of registration)

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Table 3

Peak flow values before and after intervention (median values of 14 days of registration)

DISCUSSION

This study was performed to investigate the effect of anti-allergic mattress encasings in carpet free bedrooms on Der p 1 exposure in the bed and on clinical parameters in patients with moderate to severe asthma with allergy to house dust mite. We found a significant reduction in Der p 1 concentration in the dust collected from the mattresses in the actively treated group compared with the placebo group. PC20 histamine did not improve during the 1 year intervention period. Although a significant improvement in nasal symptoms and quality of life was observed only in the actively treated group, we found no significant difference between the placebo and actively treated groups in the change in pulmonary and nasal symptoms, quality of life, peak flow values, and use of rescue medication.

Earlier studies using several different types of mattress encasings have also shown a reduction in Der p 1 exposure on top of the mattress (table 4).8-10,19,20 However, other studies did not show a reduction in Der p 1 concentrations and, remarkably, the carpets in the bedroom were not removed in these studies.21,22 We excluded the problem of Der p 1 contamination from the floor13 by including only patients who had uncarpeted floors in their bedroom. This may have contributed to the fact that we could reach a significant reduction in the actively treated group even though we had higher baseline Der P 1 concentrations than other studies.22,23 The reduction in allergen concentration was reached after 4 months and remained during the whole study period.View this table:View inline

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Table 4

Overview of results and set up of controlled mattress cover studies

Although Der p 1 concentrations were significantly reduced in the actively treated group compared with the placebo group, we did not find a significant reduction in bronchial hyperresponsiveness. Other studies have also failed to demonstrate an improvement in bronchial hyperresponsiveness.10,11,22 Two studies22,23 did not find a substantial reduction in allergen concentrations in dust, which explains the lack of improvement in bronchial hyperresponsiveness. Frederick et al10 stated that all patients were reasonably controlled on regular prophylactic treatment, so little or no change in clinical parameters could be expected. Even Cloosterman and coworkers,11 who tried to avoid this treatment effect by including only patients who either did not use inhaled steroids or were able to stop them, did not find a significant improvement in bronchial hyperresponsiveness nor in any of the clinical parameters used such as symptom score, PEF variability, and reversibility of FEV1.

How can we reconcile these observations? Patients participating in our study had severe hyperresponsiveness despite relatively high doses of inhaled corticosteroids of > 800 μg (for comparison, PC20

Clinical Evaluation of the Effect of Anti-allergic Mattress Covers in Patients with Moderate to Seve 1

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